Technology

Pharmacokinetics

The images below show the concentration of dexamethasone (μg/ml) in the tear film after topical application of either one drop of Maxidex® (dexamethasone alcoholic suspension, 1 mg/ml), ●, or aqueous dexamethasone/γCD nanoparticle eye drop suspension (15 mg/ml), ○, in rabbits and humans (Johannesson et al 2014).

pharmacokinetic mynd grey 2

Both studies show high concentration of dexamethasone in the tear film, which is maintained for 6 hours. The dexamethasone nanoparticle eye drops have a high concentration (1.5%) of dexamethasone and the nanoparticles provide sustained release for several hours.